Abstract: [Abstract] Objective To analyze the antihypertensive drug patterns of outpatients from one Grade 3A hospitals of TianJin and analyze the gap and deficiency comparing with the guidelines of china to improve the control rates of hypertension. Methods In this retrospective survey of a Grade 3A hospital ,A total of 154262 hypertension electronic prescriptions of outpatients were enrolled and varied by gender, age, seasons, drug kinds, high blood pressure level group for statistics and analysis, as the same time ,the common used patterns and the condition of combination therapy were counted. Results 1.Of the patient， most patients were receiving calcium channel blockers(52.3%）, followed by angiotensin receptor blockers (34.0%), beta-blockers (25.9%), angiotensin- converting enzyme inhibitors (12.1%), fixed-dose combination(11.0%) and diuretics (1.4%).2. Combination therapy were less than monotherapy(43.9% vs 56.1%）and there were some prescriptions which the Guideline of China do not recommend (more than 4. 4%).3.The combination therapy of stage 3 hypertension was higher than stage 1or stage 2 hypertension（44.5% vs 37.7% P<0.01）; The combinations rate of Cardiology was the highest（P<0.01）; the elderly patients tend to use more combination therapy than non-eldly patients（P<0.01）.3.The prescriptions in summer were lowest than other seasons either alone or in combinations (P <0.01).Conclusion The combination therapy and the diuretic use were insufficient. These findings indicate the existence of a gap between clinical practice and the Guideline.

Key words: outpatient prescription, antihypertensive drugs, Guideline, combination therapy