Abstract: [Abstract] At present, there is no specific antidote for local anesthetic toxicity, which seriously hindered therapeutic efficts of clinical treatment. It is increasingly urgent for finding find the effective antidote to local anesthetic. This article at? tempts to interpret the molecular pharmacological mechanism from fat pool, energy metabolism, NO, ion channel and solubili? zation for the role of fatty acids in reversal of myocardial toxicity of local anesthetics. And the different characteristics of the structure and function of nano liposome and fat emulsion were compared.

Key words: nano-liposomes, local anesthetics, myocardial toxicity, pharmacological mechanism