Abstract: Abstrsct：Objective To analyze the correlation of hyponatremia with chronic heart failure (CHF) and the prognostic
analysis of CHF. Methods Patients with CHF (n=507) and healthy adult (n=212) were included in this study. The general
data of the two groups were analysed. The index which was statistically significant was indicated as independent variables.
Multivariate logistic analysis was used to analysis the correlation between serum sodium and CHF. The relationship between
serum sodium and the prognosis of CHF include mortality and rate of readmission were included in follow-up study. The
prognostic correlation of serum sodium with BNP (brain natriuretic peptide), heart failure with preserved ejection fraction
(HFpEF, LVEF≥0.45) and heart failure with reduced ejection fraction (HFrEF, LVEF<0.45) were all analyzed. Results In⁃
dicators such as sex, smoking history showed no statistical significance between two groups (P > 0.05) while other indicators
like age, hemoglobin, serum sodium presents statistical significance (P < 0.05). Serum sodium is the protective factor for
CHF. Brain natriuretic peptide (BNP) concentration in hyponatremia group is significantly higher than that in normal serum
sodium group (P＜0.05). HFpEF and HFrEF were of no significant difference in these two groups. For patients with CHF, the
mortality in hyponatremia group is significantly higher than that in normal serum sodium group (P＜0.05), but readmission
rates were not significantly different (P＞0.05); While for patients with HFpEF, the mortality and the readmission rates were
both significantly different (P＜0.05). Conclusion Serum sodium is the protective factor in CHF, the patients with hypona⁃
tremia have higher readmission rate and death rate in HFpEF background.

Key words: hyponatremia, stroke volume , prognosis, Logistic models, risk factors, heart failure, chronic