Tianjin Med J ›› 2015, Vol. 43 ›› Issue (10): 1213-1216.doi: 10.11958/j.issn.0253-9896.2015.10.034
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CHEN Chao1, LI Jianjun2. Roles of IL-23/IL-17 axis in pathogenesis and treatment of ankylosing spondylitis[J]. Tianjin Med J, 2015, 43(10): 1213-1216.
Abstract: Abstract: The treatments for ankylosing spondylitis (AS) are still not effective, which partially due to its unclear patho⁃ genesis. Interleukin (IL)-23/IL-17 axis is a significant immunologic pathway which has attracted much attention in the past few years. This article reviewed the role of IL-23/IL-17 axis in genetic and immunological pathogenesis of AS, and intro⁃ duced the recent progresses in treatments of AS using anti-IL-23 or anti-IL-17 antibody. The important role of IL-23/IL- 17 axis in the pathogenesis and treatment of AS indicates its potential use as a new therapeutic target.
Key words: spondylitis, ankylosing, interleukin-23, interleukin-17, immunotherapy, review, IL-23/IL-17 axis
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URL: https://www.tjyybjb.ac.cn/EN/10.11958/j.issn.0253-9896.2015.10.034
https://www.tjyybjb.ac.cn/EN/Y2015/V43/I10/1213
