Abstract: Objective To explore the relationship of chemokines CXCL10-135G / A and CXCL12 - 801G / A gene polymorphisms with susceptibility to tuberculosis. Methods CXCL10-135G/A and CXCL12 -801G/A polymorphisms of 102 tuberculosis patients (case group) and 115 healthy controls (control group) were genotyped by polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP), and the relationship between the two polymorphisms and susceptibility to tuberculosis were analyzed. Results The genotype analysis of CXCL10-135G/A and CXCL12 -801G/A was in accord with the law of Hardy-Weinberg equilibrium in the case group and the control group. The differences of genotype and allele distribution frequency of CXCL10-135G/A were statistically significant between the case group and the control group (all P＜0.05). The frequency of G allele distribution was higher in the case group than that in the control group,and the frequency of A allele distribution was lower than that in the control group. There were no significant differences in genotype and allele distribution frequency of CXCL12-801G/A polymorphism between the case group and the control group(all P＞0.05). Conclusion Chemokine CXCL10-135G/A gene polymorphism is associated with susceptibility to pulmonary tuberculosis, and CXCL12-801G/A gene polymorphism may not be associated with tuberculosis infection.

Key words: 趋化因子 CXCL10, 趋化因子 CXCL12, 多态性, 单核苷酸, 结核, 肺, 疾病遗传易感性