Abstract: Reflux esophagitis is a common type of gastroesophageal reflux disease. Its pathogenesis is not completely clear, but the body immunity, oxidative stress and chemical damage have gradually become the research focus. According to the latest research, the expressions of related proteins in reflux esophagitis provide a foundation for its pathogenesis. And some kinds of proteins can be used as monitoring index in the development process from reflux esophagitis to esophageal adenocarcinoma. This article is to review the expression and significance of proteins in reflux esophagitis in recent years.

Key words: esophagitis, reflux, protein expression, research progress