Abstract: With the progress of technology and the development of severe kidney medicine, continuous renal replacement therapy (CRRT) has been extended to kidney support and has been widely used for aiming to rapidly correct fatal complications of several life-threatening renal impairment (AKI). However, there are many controversies and problems,including the timing of initiating CRRT, the dosage of treatment and the choice of filter membrane material for different kinds of critically ill patients. The controversy and study of 60 years have not come to a unanimous conclusion, which reflects the critically clinical complexity. There is no "unchangeable (one size fits all)" treatment model, but rather a "patientcentered, individualized, precision CRRT" treatment. This article was to explore these three hotspots in order to provide more evidences for clinicians to perform rationalized, personalized and precise CRRT, and to make more patients benefit from CRRT.

Key words: continuous renal replacement therapy, timing, dose, membrane