Abstract: Abstract：Objective　To investigate the effect of segmental resection combined with allogeneic bone transplantation in the treatment of giant cell tumor of bone (GCTB) around knee joint. Methods　A total of 22 patients with GCTB of knee joint admitted to our hospital from June 2010 to February 2017 were selected. All patients were treated with tumor resection combined with allogeneic bone transplantation. The American Bone and Soft Tissue Tumor Society (MSTS) score was used to evaluate the lower limb function of patients after surgery. Kellgren-Lawrence classification was used to evaluate the degree of knee osteoarthritis. The Mankin classification method was used to evaluate the postoperative excellent and good rate. At the same time, the patients were followed up, and postoperative complications and recurrence were counted. Results　There were 10 males and 12 females in 22 patients. The average age was (33.91±7.12) years. The location of GCTB: there were 8 cases at the lower femur, 14 cases of upper tibia. Campanicci grade: there were 14 cases of grade Ⅱ, 8 cases of grade Ⅲ. The MSTS score was significantly higher in patients after operation than that of preoperation (23.73±2.16 vs. 12.82±3.22, t=10.818, P＜0.05). The excellent and good rate of Mankin classification was 90.9%. Kellgren-Lawrence classification: there were 10 cases of KL 0, 10 cases of KL 1 and 2 cases of KL 2. All patients were followed up for 25 to 34 months, with an average of (30.0±2.6) months. During the follow-up period, there were 11 cases of postoperative joint degeneration aggravated, 2 cases of joint effusion, 2 cases of allogeneic rejection, and no recurrence. Conclusion　Tumor resection combined with allogeneic bone transplantation is effective in the treatment of patients with knee GCTB, and the knee function can be restored to a satisfactory state after surgery.

Key words: giant cell tumor of bone, knee joint, bone transplantation, allografts, segmental resection