Abstract: Objective To explore the imaging characteristics and associated risk factors of cystic lung disease (CLD) in
primary Sjögren's syndrome (pSS) and to provide reference for its treatment and prognosis. MethodsThe clinical and
imagine data of 181 patients with pSS in our hospital were retrospectively analyzed. According to the presence or absence of
pulmonary cystic lesions on chest CT, the patients were divided into two groups: the group with cystic lesions (51 cases) and
the group without cystic lesions (130 cases). The characteristics of chest CT of CLD related to pSS were analyzed. The
differences of clinical symptoms, physical signs and laboratory examinations were compared between the two groups by casecontrol univariate analysis. The important clinical variables and univariate P value ≤ 0.1 variables were included in the
multivariate Logistic regression analysis of possible risk factors. Results Compared with the non-cystic lesion group, there
were longer course of disease and a higher proportion of dyspnea and dry mouth symptoms in cystic lesion group (P＜0.05).
IgG, IgA, IgM, RF values, anti-SSB antibody, anti-Ro52 antibody positive ratio were higher in cystic lesion group than those
of the non-cystic lesion group (P＜0.05). The pulmonary cystic lesions were mainly round, randomly distributed and of
different sizes, with septum, blood vessels passing through or wrapping around, which could be combined with ground glass
opacity, nodular and bronchial wall thickening, rarely increased in follow-up. Multiple Logistic regression analysis revealed
that the positive anti SSB antibody was an independent risk factor of pSS related CLD (P＜0.05). Conclusion The main
characteristics of pSS related CLD are random distribution, intrathecal separation, vascular penetration or vascular wrapping.
Patients with pSS positive for anti-SSB antibodies have a higher risk of developing CLD.

Key words: Sjogren's syndrome, tomography, spiral computed, radiography, thoraciccystic, cystic lung disease, anti SSB antibody