Correlation analysis between viral load and T lymphocyte subsets in HIV/AIDS patients co-infected with syphilis infection in Guizhou province

doi:10.11958/20221797

Abstract

Abstract:

Objective To analyze the correlation between HIV-RNA load and T lymphocyte subsets in HIV/AIDS patients co-infected with syphilis in Guizhou province in recent three years. Methods A total of 2 869 newly diagnosed HIV/AIDS patients who did not receive antiretroviral therapy (ART) were selected in the public health rescue center of Guiyang from January 1, 2019 to December 31, 2021. According to results of syphilis testing, patients were divided into the simple HIV infection group (n= 2 289), the current HIV/syphilis infection group (n=333) and the previous HIV/syphilis infection group (n=247). The general demography data and the baseline data of laboratory test indicators were compared between the three groups of patients. The correlation between the HIV-RNA load and T lymphocyte subsets in different groups of HIV was analyzed. Results The age of the HIV/syphilis current infection group was lower than that of the HIV/syphilis simple infection group and the HIV/syphilis past infection group, and the proportion of males was higher than that of the HIV simple infection group and the HIV/syphilis past infection group (P<0.05). The HIV-RNA load was lower in the HIV/syphilis current infected group than that in the HIV-only infected group. CD4⁺T cells, CD8⁺T cells, and CD3⁺T cells were higher in the HIV/syphilis current infected group than those of the HIV simple infection group (P<0.05). The HIV-RNA load was higher in the HIV/syphilis previous infection group than that in the HIV/syphilis current infection group, and CD4⁺T cells, CD8⁺T cells and CD3⁺T cells were lower than those in the HIV/syphilis current infection group (P<0.05). There was no significant difference in the CD4/CD8 ratio between different HIV groups (P>0.05). The HIV-RNA load of grade Ⅰ, Ⅱ and Ⅲ decreased sequentially in the simple HIV infection group and the previous HIV/syphilis infection group (P<0.05). The HIV-RNA load of grade Ⅱ and Ⅲ in the HIV/syphilis current infection group was lower than that of grade Ⅰ (P<0.05). There was a negative correlation between HIV-RNA load and T lymphocyte subsets in the three groups of patients (P<0.01). Conclusion Changes in T lymphocyte subsets occur after HIV/syphilis co-infection. With changes in HIV-RNA load, there are also differences in the T lymphocyte subsets of HIV/syphilis co-infection.

Key words: HIV, AIDS, syphilis, viral load, T lymphocyte, Guizhou

CLC Number:

R512.91，R759.1

Figures/Tables 3

References 16

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组别	n	HIV-RNA/（log₁₀ copies/mL）	CD4⁺ T细胞/（个/μL）
单纯HIV感染组	2 289	4.71（4.00，5.31）	213.00（83.50，340.00）
HIV/梅毒现症感染组	333	4.58（3.82，5.16）^a	264.00（130.00，395.50）^a
HIV/梅毒既往感染组	247	4.79（4.08，5.43）^b	197.00（65.00，314.00）^b
H		8.836^＊	17.244^＊
组别	CD8⁺ T细胞/（个/μL）	CD3⁺ T细胞/（个/μL）	CD4/CD8
单纯HIV感染组	670.00（431.50，1 004.00）	998.00（641.00，1 435.50）	0.28（0.14，0.45）
HIV/梅毒现症感染组	784.00（510.00，1 072.50）^a	1 147.00（759.50，1 595.50）^a	0.29（0.17，0.45）
HIV/梅毒既往感染组	622.00（424.00，904.00）^b	935.00（586.00，1 299.00）^b	0.27（0.14，0.48）
H	16.780^＊	19.655^＊	2.195

组别	n	HIV-RNA/（log₁₀ copies/mL）	CD4⁺ T细胞/（个/μL）
单纯HIV感染组	2 289	4.71（4.00，5.31）	213.00（83.50，340.00）
HIV/梅毒现症感染组	333	4.58（3.82，5.16）^a	264.00（130.00，395.50）^a
HIV/梅毒既往感染组	247	4.79（4.08，5.43）^b	197.00（65.00，314.00）^b
H		8.836^＊	17.244^＊
组别	CD8⁺ T细胞/（个/μL）	CD3⁺ T细胞/（个/μL）	CD4/CD8
单纯HIV感染组	670.00（431.50，1 004.00）	998.00（641.00，1 435.50）	0.28（0.14，0.45）
HIV/梅毒现症感染组	784.00（510.00，1 072.50）^a	1 147.00（759.50，1 595.50）^a	0.29（0.17，0.45）
HIV/梅毒既往感染组	622.00（424.00，904.00）^b	935.00（586.00，1 299.00）^b	0.27（0.14，0.48）
H	16.780^＊	19.655^＊	2.195

组别	n	Ⅰ级		Ⅱ级		Ⅲ级		H
组别	n	例（%）	HIV-RNA	例（%）	HIV-RNA	例（%）	HIV-RNA	H
单纯HIV感染组	2 289	1 082（47.27）	5.15（4.53，5.66）	673（29.40）	4.47（3.89，4.95）^a	534（23.33）	4.15（3.48，4.78）^ab	391.602^＊
HIV/梅毒现症感染组	333	124（37.24）	5.01（4.24，5.54）	107（32.13）	4.50（3.81，4.85）^a	102（30.63）	4.29（3.37，4.76）^a	32.498^＊
HIV/梅毒既往感染组	247	124（50.20）	5.22（4.53，5.64）	71（28.74）	4.69（3.85，5.24）^a	52（21.05）	4.31（3.49，4.57）^ab	31.635^＊
H			3.923		2.554		0.088

组别	n	Ⅰ级		Ⅱ级		Ⅲ级		H
组别	n	例（%）	HIV-RNA	例（%）	HIV-RNA	例（%）	HIV-RNA	H
单纯HIV感染组	2 289	1 082（47.27）	5.15（4.53，5.66）	673（29.40）	4.47（3.89，4.95）^a	534（23.33）	4.15（3.48，4.78）^ab	391.602^＊
HIV/梅毒现症感染组	333	124（37.24）	5.01（4.24，5.54）	107（32.13）	4.50（3.81，4.85）^a	102（30.63）	4.29（3.37，4.76）^a	32.498^＊
HIV/梅毒既往感染组	247	124（50.20）	5.22（4.53，5.64）	71（28.74）	4.69（3.85，5.24）^a	52（21.05）	4.31（3.49，4.57）^ab	31.635^＊
H			3.923		2.554		0.088

组别	CD4⁺ T细胞	CD8⁺ T细胞	CD3⁺ T细胞	CD4/CD8
单纯HIV感染组	-0.467^＊＊	-0.199^＊＊	-0.290^＊＊	-0.451^＊＊
HIV/梅毒现症感染组	-0.375^＊＊	-0.148^＊＊	-0.229^＊＊	-0.395^＊＊
HIV/梅毒既往感染组	-0.456^＊＊	-0.170^＊＊	-0.265^＊＊	-0.486^＊＊