Abstract: Gitelman’s syndrome (GS) is an autosomal recessive hereditary tubulopathy. It is caused by sodium reabsorption in the distal convoluted tubule of the renal unit, which is not yet fully cured. It is characterized by great heterogeneity with clinical manifestations. Some patients with no symptoms, were confirmed by hypokalemia with physical examination. The others can be manifested as fatigue, nocturia, polydipsia and hypotension. Less literature is reported about GS combined with osteoarthrosis. In this report, the author reported a patient of GS with osteoarthrosis characterized by hypokalemia, hypomagnesemia, metabolic alkalosis, lower blood pressure, and swelling and pain in left knee joint. Thesymptoms were improved after treatment with potassium and magnesium supplementation

Key words: Gitelman's syndrome, hypokalemia, osteoarthritis, cartilage calcification