Abstract: [ Abstract ]：The activation of p21 kinase 2 ( p21-activated kinase2 ), PAK2, has the value for cancer research, owing to its participation in a series of intracellular biological activity, and the relationship between PAK2 and tumor progression has been studied in few studies. PAK2 can be activated by a variety of upstream signal especially small G protein Rho family of Rac and Cdc42, and it participate in a variety of important signaling pathways and cell function regulation. Abnormal of PAK2 has been reported in various tumors, which involves in cytoskeletal remodeling, cell motility, apoptosis, signal transduction, gene transcription, translation and angiogenesis, and PAK2 plays an important role in tumor occurrence and development. Therefore, the research about PAK2 and the targeting therapy for anti-PAK2 provides a new sight on the treatment and prevention of tumor.

Key words: PAK2, Biological Characteristics, Tumor.