Abstract: Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a serious adverse drug reaction,characterized with rash, fever, lymphadenectasis, eosinophilia and visceral involvement. This article describes the clinical case of a patient with renal insufficiency after receiving sensitizing drugs，which resulted in limb weakness and cognitive impairment of center nervous system characterized by vasculitis imaging and responded well to glucocorticoid treatmentDRESS syndrome.

Key words: brain infarction, vasculitic-like, central nervous system, drug rash, eosinophilia, adverse drug reaction