Abstract: Abstract: CD4+ T cells can differentiate into a variety of auxiliary T cells (Th cells) and regulatory T cells (Treg) after the stimulation of antigen, which is an important part of human immune system. With the further study of aplastic anemia and CD4+ T cells, it is found that the imbalance of CD4+ T cell subsets, hyperfunction and bone marrow injury caused by abnormal activation of cytokines are important causes of the pathogenesis of aplastic anemia. Therefore, the study of cell differentiation and regulation of CD4+ T cells and the analysis of the mechanism of CD4+ T cells in aplastic anemia can provide therapeutic ideas for the recovery of cell subpopulation balance in patients with aplastic anemia. In this paper, the effects of CD4+ T cell immune abnormalities on the mechanism and treatment of aplastic anemia were discussed from the aspects of CD4+ T cells and related cytokines.

Key words: anemia, aplastic, review, CD4+ T cells, Th1, Th2, Treg, Th17