Research progress on effects of sevoflurane on apoptosis related signal pathways of hippocampal neurons

doi:10.11958/20212285

Abstract

Abstract:

Sevoflurane is a widely used inhalation anesthetic, and there is growing concern about its effects on cognitive function. Sevoflurane can cause neurotoxicity, resulting in neuronal damage, apoptosis and cognitive dysfunction. Neuronal apoptotic pathways include the endogenous apoptotic pathway, the exogenous apoptotic pathway and the endoplasmic reticulum pathway. Apoptosis-related signaling pathways, such as phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK), play an important role in these pathways. This paper reviews the recent literature in this field and provides a review of the possible signaling pathways involved in sevoflurane-induced apoptosis in hippocampal neuronal cells.

Key words: Sevoflurane, apoptosis, hippocampus, signal pathway, review

CLC Number:

R614

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