Abstract: Abstract： Objective　To study the efficacy of Kudiezi injection plus low molecular weight heparin (LMWH) on preventing deep venous thrombosis (DVT) in elderly patients with lower limb fracture surgery. Methods　Totally 120 senile patients (≥60 years old) with lower limb fracture were randomly divided into control group (CG, n=58) and treatment group (TG, n = 62). CG was received LMWH 12 h after surgery. TG was given Kudiezi injection and LMWH. Data of hemorheology (whole high blood viscosity, whole low blood viscosity and plasma viscosity), D-dimer, coagulation function (prothrombin time, activated partial thromboplastin time) and inflammatory factors (tumor necrosis factor-α, interleukin-6, interleukin-8) before surgery and 7 days after surgery were compared between CG and TG. Pain scores of 1, 3, 5 and 7 days postoperatively were recorded with numerical rating scale in two groups. Circumference differences of fracture and healthy thigh and shank were measured before surgery and 3 and 7 days after surgery. Incidences of DVT and adverse reactions within 30 days were followed up. Results No significant differences were observed in preoperative indexes between the two groups (P＞0.05). Data of hemorheology, D-dimer, coagulation function and inflammatory factors were decreased 7 days after surgery in TG versus CG (P＜0.05), and no significant differences in coagulation index were found between the two groups (P＞0.05). Pain scores of 3, 5 and 7 days after surgery were decreased in TG compared with those in CG (P＜0.01). Differences in circumference of fracture and healthy thigh and shank were lower 7 days after surgery in TG than those in CG (P＜0.01). The incidence of DVT was lower in TG (3.23%) than that of CG (13.79%, P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (4.84% and 3.45%, P＞0.05). Conclusion Kudiezi injection combined with LMWH can decrease the postoperative levels of hemorheology and inflammatory factors, alleviate pain and swelling of affected extremity, and reduce the incidence of DVT in elderly patients with lower limb fracture.

Key words: heparin, low-molecular-weight, fracture, lower limb, venous thrombosis, aged, Kudiezi Injection