Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disease. A number of studies have shown that α-synuclein (α-syn) is closely related to the pathogenesis of Parkinson's disease. Domestic and foreign researchers have established PD animal models via the ectopic expression, overexpression or intracerebral injection of α-syn. In recent years, α-synuclein preformed fibrils (α-syn PFFs) have been used in the construction of animal models. α-syn PFFs play an important role in the study of the origin of PD and the transmission of neuronal degeneration. Compared with the toxin-induced models, these models can better reproduce the characteristics of pathological changes of PD patients. In this article, we mainly reviewed the research progress in α-synuclein-based animal models of PD.