Abstract: Objective　To analyze the application value of 3D printing artificial vertebral body for spinal cord reconstruction after total vertebrectomy for spinal tumors. Methods　Data of 11 patients in our hospital who used 3D printed artificial vertebrae for reconstruction after total vertebral tumor resection was analyzed. The operation time, intraoperative blood loss, hospital stay, internal fixation stability, and visual analogue rating scale (VAS) score were recorded. The degree of pain before operation, 24 hours after operation, 6 months after operation and the last follow-up were evaluated. The spinal function at the above time points was evaluated according to the evaluation treatment score of the Japanese Orthopaedic Association (JOA). At the last follow-up, the severity of spinal cord injury was analyzed by Frankel classification, and complications were recorded during the follow-up. Results　Patients were followed up for 8 to 15 months, with an average of 11 months. The operation time was (320.21±43.21) min, the amount of bleeding was (1 354.28±101.54) mL, and the hospital stay was (22.21±10.24) d. Ten of the 11 patients had at least 1 grade improvement in Frankel classification at the last follow-up. There was no movement or breakage of the pedicle screw position in all patients, and no dislocation of the prosthesis. The VAS scores showed a decreasing trend before surgery, 24 hours after surgery, and 6 months after surgery (P＜0.01); but there was no significant difference in VAS score between the last follow-up and 6-month after surgery. There were no significant differences in JOA scores before and 24 hours after surgery, and the JOA scores showed a sequential upward trend at other time points (P＜0.01). One patient with giant cell tumor of bone recurred 3 months after operation, and one patient with secondary thyroid cancer to spine died 9 months after opertion. Conclusion　The application of 3D printing artificial vertebral body after total vertebrectomy for spinal tumors has high stability, less complications, high safety and good prognosis.

Key words: spinal neoplasms, total vertebral resection, 3D printing technology, stability