Abstract: Objective　To explore the correlation between meteorological parameters and outcome in patients with acute ischemic stroke (AIS) in Tangshan area. Methods　A total of 636 patients with AIS admitted to the Department of Neurology of Tangshan Xiehe Hospital were enrolled retrospectively. Clinical outcome was assessed by the modified Rankin scale (mRS) at 3 months after onset. The score of 0-2 was defined as the good outcome, and >2 was defined as the poor outcome. A total of 636 patients were enrolled in the study, and 413 had good outcome, 223 had poor outcome. Clinical basic data, laboratory tests and meteorological parameters were compared between the two groups. Multivariate Logistic regression analysis was used to determine the independent risk factors for poor outcome in patients with AIS. Results　The values of age, the proportion of women and history of stroke, systolic pressure at admission, baseline National Institutes of Health Stroke Scale (NIHSS) score, the proportion of complicated pneumonia, white blood cell count (WBC), fibrinogen (FIB), daily range of temperature, average daily wind speed and daily maximum wind speed were higher in the poor outcome group than those in the good outcome group (P＜0.05). However, the values of albumin (ALB), red blood cell count (RBC), hemoglobin (HGB), average daily temperature and average daily relative humidity were significantly lower in the poor outcome group than those in the good outcome group (all P＜0.05). Multivariate Logistic regression analysis showed that high NIHSS score, high daily range of temperature and rapid daily maximum wind speed were independent risk factors for poor outcome in patients with AIS (P＜0.05). Conclusion　Daily range of temperature and daily maximum wind speed are significantly correlated with outcome in patients with AIS.

Key words: stroke, brain ischemia, treatment outcome, medical meteorology, risk factors