Correlation between serum MIF, 25(OH)D and cognitive function in patients with vestibular migraine

doi:10.11958/20251691

Abstract

Abstract:

Objective To explore the correlation between serum macrophage migration inhibitory factor (MIF), 25-hydroxyvitamin D [25(OH)D] and cognitive function in patients with vestibular migraine (VM). Methods A total of 200 patients with VM were selected and used as the VM group. Based on the Montreal Cognitive Assessment (MoCA) criteria, patients were divided into the cognitively normal group (128 cases) and the cognitively impaired group (72 cases). Additionally, 200 healthy individuals undergoing routine health examination were selected as the control group. Serum MIF and 25(OH)D levels were measured using enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze influencing factors of cognitive impairment in VM patients. The value of serum MIF and 25(OH)D levels in diagnosing cognitive impairment in patients with VM was analyzed by using the receiver operating characteristic (ROC) curve. Results The serum MIF was higher in the VM group than that of the control group, and serum 25(OH)D was lower in the VM group (P<0.05). The serum MIF was higher in the cognitive impairment group than that of the cognitive normal group, while the serum 25(OH)D was lower in the cognitive impairment group than that of the cognitive normal group (P<0.05). Multivariate Logistic regression found that increased serum MIF level and decreased 25(OH)D level were independent risk factors for cognitive impairment in VM patients (P<0.05). ROC curve analysis showed that the AUC (95%CI) of the combined diagnosis of cognitive impairment in VM patients using serum MIF and 25(OH)D levels was 0.900 (0.850-0.938), which was higher than that of MIF diagnosed alone [0.797 (0.735-0.851)] and 25(OH)D alone [0.817 (0.756-0.868), P<0.05]. Conclusion VM patients with cognitive impairment have elevated serum MIF levels and decreased 25(OH)D levels. The combined diagnostic value of the two markers has a relatively high value for VM patients with cognitive impairment.

Key words: migraine, macrophage migration-inhibitory factors, cognitive dysfunction, 25-hydroxyvitamin D, vestibular migraine

CLC Number:

R747.2

Figures/Tables 5

References 21

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组别	n	年龄/岁	性别（男/女）	BMI/（kg/m²）
对照组	200	41.84±6.71	87/113	22.67±3.05
VM组	200	41.07±6.87	81/119	22.41±3.16
t或χ²		1.134	0.369	0.837
组别	受教育程度（高中及以上/高中以下）		居住地（城市/农村）	吸烟史
对照组	92/108		107/93	42（21.00）
VM组	87/113		100/100	48（24.00）
χ²	0.154		0.491	0.516
组别	饮酒史		MIF/（μg/L）	25（OH）D/（μg/L）
对照组	46（23.00）		18.34±3.84	33.42±6.74
VM组	54（27.00）		33.09±6.44	19.89±3.85
t或χ²	0.853		27.820^＊	24.651^＊

组别	n	年龄/岁	性别（男/女）	BMI/（kg/m²）
对照组	200	41.84±6.71	87/113	22.67±3.05
VM组	200	41.07±6.87	81/119	22.41±3.16
t或χ²		1.134	0.369	0.837
组别	受教育程度（高中及以上/高中以下）		居住地（城市/农村）	吸烟史
对照组	92/108		107/93	42（21.00）
VM组	87/113		100/100	48（24.00）
χ²	0.154		0.491	0.516
组别	饮酒史		MIF/（μg/L）	25（OH）D/（μg/L）
对照组	46（23.00）		18.34±3.84	33.42±6.74
VM组	54（27.00）		33.09±6.44	19.89±3.85
t或χ²	0.853		27.820^＊	24.651^＊

组别	n	年龄/岁	性别（男/女）	BMI/（kg/m²）
认知正常组	128	40.89±7.24	51/77	22.45±3.22
认知障碍组	72	41.38±6.21	30/42	22.34±3.05
t或χ²		0.483	0.064	0.236
组别	受教育程度（高中及以上/高中以下）		居住地（城市/农村）		吸烟史
认知正常组	54/74		62/66		30（23.44）
认知障碍组	33/39		38/34		18（25.00）
χ²	0.249		0.347		0.062
组别	饮酒史		MIF/（μg/L）		25（OH）D/（μg/L）
认知正常组	30（23.44）		30.51±6.05		21.61±4.13
认知障碍组	24（33.33）		37.67±7.14		16.83±3.34
t或χ²	2.289		7.521^＊		8.395^＊

组别	n	年龄/岁	性别（男/女）	BMI/（kg/m²）
认知正常组	128	40.89±7.24	51/77	22.45±3.22
认知障碍组	72	41.38±6.21	30/42	22.34±3.05
t或χ²		0.483	0.064	0.236
组别	受教育程度（高中及以上/高中以下）		居住地（城市/农村）		吸烟史
认知正常组	54/74		62/66		30（23.44）
认知障碍组	33/39		38/34		18（25.00）
χ²	0.249		0.347		0.062
组别	饮酒史		MIF/（μg/L）		25（OH）D/（μg/L）
认知正常组	30（23.44）		30.51±6.05		21.61±4.13
认知障碍组	24（33.33）		37.67±7.14		16.83±3.34
t或χ²	2.289		7.521^＊		8.395^＊

变量	β	SE	Wald χ²	P	OR	OR 95%CI
MIF	2.336	0.351	44.286	<0.001	10.338	5.196~20.569
25（OH）D	-0.603	0.153	15.549	<0.001	0.547	0.405~0.738
常数项	-3.842	0.563	102.378	<0.001	0.005