Observation on the efficacy of millimeter wave adjuvant therapy for knee osteoarthritis

doi:10.11958/20260057

Abstract

Abstract:

Objective To evaluate the efficacy of millimeter wave adjuvant therapy on knee osteoarthritis (KOA) and the influence on peripheral blood T helper type 1/T helper type 2 (Th1/Th2) cytokine balance. Methods A total of 90 patients with KOA were selected and randomly assigned into the control group (conventional comprehensive therapy, 45 cases) and the observation group (conventional comprehensive therapy plus millimeter wave adjuvant therapy, 45 cases). The clinical efficacy, pain visual analogue scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), knee range of motion (ROM), levels of peripheral blood Th1/Th2 cytokines and adverse reactions were compared between the two groups of patients. Results After 12 weeks of treatment, the total effective rate was higher in the observation group than that in the control group (P<0.05). Pain VAS scores after 4, 8 and 12 weeks of treatment were lower in the observation group compared to those of the control group (P<0.05). After 12 weeks of treatment, WOMAC scores, IL-2 and IFN-γ levels were lower in the observation group compared to those of the control group, and ROM, IL-4 and IL-10 were higher (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Millimeter wave adjuvant therapy can regulate the peripheral blood Th1/Th2 cytokine balance, effectively relieve the joint pain and improve the knee function in KOA patients, with good safety.

Key words: osteoarthritis, knee, Th1 cells, Th2 cells, cytokines, arthralgia, millimeter wave

CLC Number:

R684.3

Figures/Tables 5

References 26

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组别	性别（男/女）	年龄/岁	病程/年	K-L分级（Ⅱ/Ⅲ）
对照组	18/27	62.35±7.12	5.28±2.15	21/24
观察组	20/25	61.87±6.95	5.03±2.08	23/22
χ²或t	0.182	0.324	0.561	0.178
组别	体质量指数/（kg/m²）		高血压	糖尿病	高脂血症
对照组	25.64±2.31		12（26.67）	7（15.56）	9（20.00）
观察组	25.38±2.27		11（24.44）	8（17.78）	10（22.22）
χ²或t	0.539		0.058	0.080	0.067

组别	性别（男/女）	年龄/岁	病程/年	K-L分级（Ⅱ/Ⅲ）
对照组	18/27	62.35±7.12	5.28±2.15	21/24
观察组	20/25	61.87±6.95	5.03±2.08	23/22
χ²或t	0.182	0.324	0.561	0.178
组别	体质量指数/（kg/m²）		高血压	糖尿病	高脂血症
对照组	25.64±2.31		12（26.67）	7（15.56）	9（20.00）
观察组	25.38±2.27		11（24.44）	8（17.78）	10（22.22）
χ²或t	0.539		0.058	0.080	0.067

组别	显效	有效	无效	总有效
对照组	16（35.56）	18（40.00）	11（24.44）	34（75.56）
观察组	28（62.22）	14（31.11）	3（6.67）	42（93.33）
χ²				5.414^＊

组别	显效	有效	无效	总有效
对照组	16（35.56）	18（40.00）	11（24.44）	34（75.56）
观察组	28（62.22）	14（31.11）	3（6.67）	42（93.33）
χ²				5.414^＊

组别	治疗前	治疗4周	治疗8周	治疗12周
对照组	6.85±1.23	5.12±1.05^a	3.76±0.89^a	2.89±0.76^a
观察组	6.92±1.18	3.87±0.96^a	2.45±0.78^a	1.63±0.65^a
t	0.275	5.894^＊＊	7.426^＊＊	8.452^＊＊
F_组间/F_时间/F_交互	86.330^＊＊/401.400^＊＊/11.101^＊＊