Abstract: Mesenchymal stem cells (MSCs) are defined as undifferentiated cells that are capable of self renewal and functionally capable of differentiating into adipocytes, osteoblasts, chondrocytes, hepatocyte-like cells, myogenic-like cells, neuron-like cells, and islet-like cells. MSCs possess immunomodulatory properties according to secrete indoleamine-2,3- dioxygenase (IDO) and prostaglandin E2 (PGE2) to play the role of immunomodulatory. Moreover, pre-stimulation of interferon- γ (IFN- γ) can promote the immunomodulatory function of MSCs. High abundance of MSCs found in adipose tissue makes it a very attractive source of adult stem cells. This article reviews the recent progress in the interaction between adipose derived mesenchymal stem cells (ADSCs) and three immunomodulatory factors.

Key words: dinoprostone, neuroimmunomodulation, cytokines, review, adipose-derived mesenchymal stem cells, indoleamine-2,3-dioxygenas