Abstract: 0bjective： To explore the high risk factors of coronary artery lesions(CALs)caused by Kawasaki disease. Methods :Clinical data of 1070 patients with KD admitted in our department from January 1997 to September 2011 were collected and retrospectively reviewed.Risk factors associated with coronary artery lesions including gender，age，duration of fever，use of intravenous gamma immune globulin (IVIG)，white blood cell count(WBC),platelet count(PLT),hematocrit(Hct)， C-reactive protein (CRP),erythrocyte sedimentation rate(ESR),and serum albumin(Alb) were analysed．Chi-square test and Logistic regression were performed． Results: Chi-square test showed that gender，age，duration of fever，timing of IVIG treatment，WBC，CRP,and PLT were significantly related to CALs(P <0.05).Multiple Logistic regression analysis identified CRP ,PLT,age ,sex as risk factors of CALs (P < 0.05)． Conclusions :Less than 1 year old age ,male,and high level of CRP and PLT are the high risk factors of CALs caused by Kawasaki disease．

Key words: Kawasaki disease, coronary artery lesions, Logistic regression, high risk factor