Abstract: Abstract   Objective     To explore pathogenic etiology and clinical features of catheter-related bloodstream infection(CRBSI), and to provide basis for the empiric therapy of CRBSI．Methods  All patients who had the definite diagnosis of CRBSI were investigated from Feb,2011 to Oct, 2012 in Tianjin People,s Hospital.The pathogens, clinical features, inflammatory markers，and prognosis were analyzed retrospectively．Result  There were 91 pathogenic strains isolated from 91 patients who were diagnosed as CRBSI．In which 31 strains (34.1% ) were fungi, 31 strains (34.1% ) were gram-negative bacilli，29 strains （31.9%）were gram-positive cocci. There was no difference in the constituent ratio between three groups (P>0.05). CRBSI clinical features caused by fungi and gram-negative bacilli present hyperpyrexia with shiver. Low or moderate fever without shiver were more frequent in gram-positive cocci group. Inflammatory markers level in Three groups of pathogens rised, but were more higher in fungi and gram-negative bacilli group.mortality rate was more higher in fungi group（p< 0.05）.Conclusion    Fungi, gram-negative bacilli and gram-positive cocci are equally pathogenic strains of CRBSl. Investigation of pathogens of CRBSI should be strengthened and empiric antibiotic therapy based on clinical features should be given early to reduce mortality rate.

Key words: catheter-related bloodstream infection, pathogens, Clinical features