Abstract: Objective  To compare the efficiency of tranexamic acid single dose intraarticular injection and autologous transfusion drain on the blood loss post total knee arthroplasty (TKA). Methods  124 patients (124 knees) with varus knee osteoarthritis performed TKA were retrospectively analyzed, 24 males and 100 females, the mean age was 65.03 years. Due to the blood loss control methods, two groups were divided as TXA application group (test group, n = 49) and autologous transfusion drain group (control group, n =75). The blood loss and blood transfusion characters were analyzed. Results   The allogeneic blood transfusion ratio 7 days post TKA surgery was 10.20% (5/49) in the test group and 17.33% (13/75) in the control group group (P＞0.05). The RBC, Hb, HCT all had statistics difference according to test period, between groups and effects of interaction in the two groups(P＜0.05). Significant difference was found when the RBC, Hb and HCT were compared at the 1,3,7 day post TKA between the two groups (P＜0.05), while the total blood loss post TKA showed no statistic difference (P＞0.05). Conclusion   Compared with autologous transfusion drain, single dose intraarticular injection of tranexamic acid 500 mg can significantly improve the levels of RBC, Hb and HCT at the day 1, 3 and 7 after TKA. However, the blood transfusion ratio, total blood loss and Hb decline in 7 days post TKA showed no significant difference in the two groups.

Key words: knee prosthesis, arthroplasty, replacement, knee, tranexamic acid, blood transfusion, autologous, 自体