Abstract: [Abstract] Objective   To Summarize the clinical characteristics and the experience of diagnosis and treatment in the neonatal cow's milk protein allergy(CMPA) with the original symptom similar to sepsis. Methods   10 patients with neonatal cow's milk protein allergy(CMPA) with the original symptom similar to sepsis hospitalized in our hospital from July 2009 to December 2013.The history data, clinical manifestation, laboratory examination results and the treatment outcome of them were retrospectively analyzed. Results   In 10 cases,6 cases have a family history of allergy. Main clinical manifestations in the skin and gastrointestinal symptoms, including 1 case of anaphylactic shock. IgE mediated 6 cases, acidophilic cells count (1.40±0.17)×109/L,the percentage was greater than 5%;4 cases of non IgE mediated, acidophilic cells count (0.71±0.08)×109/L,the percentage was 2-3%. Blood cultures were all negative, blood leukocyte count (24.5±3.3)×109/L,rod nucleus granulocyte/neutrophils (0.161±0.035),the platelet count (655±39)×109/L, blood interleukin (IL)-6,0.31-0.93 ug/L,C reactive protein (CRP),85-144mg/L.10 cases with extensively hydrolyzed formular or amino acid formular feeding, the clinical symptoms improved or disappeared significantly, the inflammatory indexes returned to normal. Conclusion   It is necessary to make the differential diagnosis between sepsis and neonatal CMPA，which accompanied by increased platelet and acidophil. The most important treatment of neonatal CMPA is hypoallergenic formular replacement therapy.

Key words: milk hypersensitivity, sepsis, newborn, diagnosis, differential, cow's milk protein allergy