Abstract:

[Abstract] Objective  To explore the correlation between serum gamma glutamyltransferase (γ-GGT) and cardio vascular risk factors in different genders with type 2 diabetes mellitus. Methods  A total of 286 patients with type 2 diabetes were divided into male group and female group, and then each group was sub-divided into four groups according to the quartile of serum γ-GGT level. The values of body mass index (BMI), waist, systolic pressure (SBP), diastolic pressure (DBP), triglyceride (TG), cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), high sensitive c-reactive protein (hsCRP) and uric acid (UA) were compared between groups. Results  There were significant differences in BMI, waist, DBP, TG, TC, UA，γ-GGT，age, HDL-C，HbA1c，hsCRP and plasma fibrinogen (FIB) between different genders with type 2 diabetes mellitus. There were significant differences in age，duration of disease，BMI, waist, SBP, DBP, TG, TC, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in male subjects with different γ-GGT levels. There were significant differences in waist, TC, LDL-C, hsCRP, ALT,AST and alkaline phosphatase (ALP) in female. The level of γ-GGT was negatively correlated with age and duration of disease in male patients. But it was positively correlated with BMI, waist, DBP, TG, TC, hsCRP and UA in male patients. In female patients, the level of γ-GGT was positively correlated with waist, TC, LDL-C, HbA1c, hsCRP and UA. Values of BMI and TC were the independent risk factors of γ-GGT in male patients. Values of waist and hsCRP were the independent risk factors of γ-GGT in female patients. Conclusion  The serum γ-GGT is closely related with several cardiovascular risk factors in patients with type 2 diabetes mellitus, which deserves attention and research in predicting the cardiovascular complication of diabetes.

Key words: diabetes mellitus, type 2, risk factor, dyslipidemias, high sensitive c-reactive protein, gamma glutamyltransferase