Abstract: Abstract Objective: To investigate Association of white blood cell count (WBCC) with glucose and lipid metabolism and cardiovascular risk factors in obese children. Methods: A total of 111 subjects,84 boys and 27girls aged 8 – 15 years were enrolled. The subjects were divided into four quartiles according to WBCC (WBCC1 – 4, from the lowest to highest WBCC) in both genders. The mean values of glucose and lipid metabolism and cardiovascular risk factors for each group were compared in boys and girls separately. Bivariate correlation analysis used to compare the relationship between WBCC and glucose and lipid metabolism and cardiovascular risk factors. Multiple regression analysis used to evaluate the factors affecting the level of WBC count. ResultS: The boys had signi?cantly higher WBCC, BMI, WC and triglyceride (TG) than the girls. While there was no significant differences in the systolic blood pressure（SBP）, diastolic blood pressure（DBP）,fasting blood glucose(FPG), high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (HDL-C).，total cholesterol(TC). When comparing the risks of the quartiles of WBCC, In both genders, WBCC4 had signi?cant higher the BMI and WC than WBCC1.In addition, TG and AI of WBCC4 was signi?cantly higher than WBCC1 while HDL-C of WBCC4 was lower than WBCC1 and WBCC2 in boys. WBCC was positively related with BMI, WC,TG,AI and negatively related with HDL-C among boys, whereas in girls only BMI and WC was positively related with WBCC. Multiple stepwise regression analysis showed that the main factors affecting white blood cell count for the TG, WC, HDL-C. Conclusions：White blood cell count as a marker of inflammation, the ravelence of it and central obesity, dyslipidemia and glucose metabolism are closely. Elevated white blood cell count in obese children could become an important cardiovascular disease risk factors, involved in lipid disorders and cardiovascular diseases development.

Key words: children, glucose and lipid metabolism, white blood cell count, cardiovascular risk factors