Abstract:

[Abstract] Objective  To investigate the safety and efficacy of hydroxychloroquine plus low-molecular-weight heparin and glucocorticoids in pregnant women with antiphospholipid syndrome (APS). Methods  Clinical data of 12 pregnant women with APS were retrospectively analyzed. Eight patients were APS secondary to connective tissue disease while four were primary APS. Hydroxychloroquine plus low-molecular-weight heparin was employed for the treatment of all the patients，among some of whom undergone combined glucocorticoids therapy. Results  All patients underwent a successful delivery with no abnormalities and are with normal Apgar scores of the babies. No compliations were developed during a follow up of 2-15 months. Conclusion  Hydroxychloroquine plus low-molecular-weight heparin and glucocorticoids is safe and effective in treatment of pregnant women with APS, but its clinical value needs further investigate

Key words: antiphospholipid syndrome, hydroxychloroquine, heparin, low-molecular-weight, pregnancy