Abstract:

[Abstract] Objective  To explore the protective effect of pre-operation administration of nicorandil on myocardial injury and recurrent angina in patients with unstable angina pectoris who underwent percutaneous coronary intervention (PCI). Methods  A total of 91 patients with unstable angina pectoris were admitted for PCI and randomly divided into 2 groups who either received nicorandil（5 mg tid）or not for 7 days prior to the procedure and routine dose of nicorandil (5mg tid) after it．The concentrations of creatine kinase MB (CK-MB) and cardiac troponin I(cTnI) were compared between two groups before PCI and 6 hours, 18 hours and 24 hours after PCI；Recurent angina and major adverse cardiac events，includ? ing death，re-infarction and stroke at 6 months after the procedure were also chased and compared.  Results In total, 75 patients who were successfully undergone elective PC1 were finally enrolled，among whom 37 cases were in nicorandil group and 38 cases were in routine group． Post-procedural levels of CK-MB and cTnI significantly reduced in the nicorandil group between 6～24 h (P < 0.05) compared those in routine group．At 6 months follow-up，symptoms of recurrent angina after PCI were significantly relieved in the nicorandil group compared with that in routine group (P < 0.05)．Conclusion nicorandil can limit the PCI-induced myocardial injury and relieve the symptoms of recurrent angina after PCI in patients with unstable angina．

Key words: Percutaneous Coronary Intervention, troponin Ⅰ, Nicorandil, recurrent angina