Abstract: Abstract Objective: To analyze if there are relationships between the portal vein pressure preoperation(PVP)/descendent level of portal vein pressure postoperation(DPVP) and portal vein thrombosis in patients after splenectomy for portal hypertension due to cirrhosis resulting from hepatitis. Methods: The clinical data of 226 patients with hypertension due to cirrhosis resulting from hepatitis receiving simple splenectomy or splenectomy and portal-azygous devascularization in our hospital from August 2000 to June 2007 were retrospectively analyzed. The effective cases were 154. the cases were divided into 2 groups according to with or without portal vein thrombosis, relation of portal vein thrombosis to PVP and DPVP was analyzed. Accord to the DPVP, the cases were divided into ≤8cmH2O and >8cmH2O 2 groups, and we analyzed the rate of portal vein thrombosis between the 2 groups. Average comprision was studied by student-t test or nonparametric test, rate comprision was studied by chi-square test. Results: The portal vein thrombosis occurred in 31 patients and 123 patients had no thrombosis occurred. Our analysis showed that the PVP of the group with thrombosis was higher than the group without thrombosis, the DPVP of the group with thrombosis was higher than the group without thrombosis(P<0.05). The rate of thrombosis occurrence in the DPVP>8cmH2O group was greater than in the DPVP≤8cmH2O group. Conclusion: The PVP and the DPVP are important factors to portal vein thrombosis in patients after splenectomy for portal hypertension due to cirrhosis resulting from hepatitis. The higher the DPVP was, the greater odds of the portal vein thrombosis occur.

Key words: Portal hypertension, Portal vein thrombosis, portal vein pressure, Splenectomy