Abstract: Abstract:Objective To observe bone marrow endothelial progenitor cell’s (EPC) differentiation to endothelial cell on corpus luteum of pseudocyesis rat and the participation in vasculogenesis;Methods From caudal vein, female rats that rediated by 137Cs were transplantated EPCs marked DAPI of male rats, made pseudocyesis model of transplantated female rats after hematopoietic reconstitution,then on the 7th day, observed EPCs’ distribution and differentiation on the female rats’ bone marrow, peripheral blood and corpus luteum by fluorescence microscopy and in situ hybridization SRY;Results cells marked DAPI dispersed on models’ bone marrow, peripheral blood and corpus luteum, and male rat’s EPCs marked SRY appeared on the capillary of model rats’ corpus luteum; Conclusions EPCs start differentiation to endothelial cells and participate in vasculogenesis on pseudocyesis rats corpus luteum.

Key words: endothelial progenitor cell, endothelial cell, corpus luteum, differentiation, vascu-logenesis