Abstract: Abstract Objective: To investigate the predict effect of pregnancy associated plasma protein A(PAPP-A) and macrophage inhibitory cytokine-1(MIC-1) on miscarriage in the early pregnancy period. Methods: From July 2010 to July 2011, we collected gestation maternal serum at 6-12 weeks of pregnancy and tracked the outcome of pregnancy. During observation period, all of 20 pregnant women appeared miscarriage (miscarriage group). Their serum levels of PAPP-A and MIC-1 were compared with 120 normal pregnant women (control group). Results: PAPP-A and MIC-1 level in the miscarriage group were lower than in the control group at 6-12 weeks of pregnancy (P <0.05). In the multivariate logistic regression analysis, PAPP-A (OR, 95% CI: 0.79-0.84) and MIC-1 (OR, 95% CI: 0.83, 0.77-0.90) was negatively correlated with miscarriage. Conclusion: In the early stage of pregnancy, PAPP-A and MIC-1 could predict miscarriage effectively. When the two indicators appeared a low level, clinicians should take appropriate treatment to ensure gestation.

Key words: pregnancy associated plasma protein A, macrophage inhibitory cytokine-1, miscarriage, prediction