Abstract: Objective : To investigate the clinical medicine and drug resistance of pan-drug resistant Acinetobacter baumannii in the respiratory department in order to offer reference for the clinical therapeutics. Methods: The 283 strains of pan-drug resistant Acinetobacter baumannii were retrospective statistical analyzed about the result of sensitivity to antibiotics in the respiratory department from 2010 to 2012.The disk diffusion method was employed to detect the drug-resistance ratio. Results: Clinical infection of pan-drug resistant Acinetobacter baumannii had various degree of drug-resistance rate to fourteen different antibiotic agents,The highest rate of drug-resistance ratio was ceftazidime(93.4%)and the lowest of drug-resistance ratio to imipenem was 1.9%.Tne drug-resistance ratio of imipenem, cefoperazone/sulbactam, ampicillin/sulbactam , minocycline, amikacin and so on were low by comparision. Conclusion: Clinical infection of pan-drug resistant Acinetobacter baumannii had rather high drug-resistance rate to fourtheen different antibiotic agents in the respiratory department . More attention shoud be paid to provide theoretical and objective basis for clinical uses rationally.