Abstract:

 [Abstract]   Objective  To investigate the expressions of DKK1，SFRP4and Wnt1in cervical squamous cell carcino-ma(SCC), and the clinical significance thereof.   Methods   There were76samples of cervical squamous cell carcinoma were included in SCC group and 36benign uterine resection specimens were control group (NC). The immunohistochemical method was applied to detect the expressions of DKK1，SFRP4and Wnt1in two groups.    Results   The expression of DKK1was significantly lower in SCC group than that in NC group (P<0.05). The expression levels of SFRP4and Wnt1were significantly higher in SCC group than those of NC group (P<0.05). There were significant differences in the expressions of DKK1，SFRP4and Wnt1between samples of different clinical staging, differentiation, sizes of tumor and lymph node metastasis (P<0.05). The expression of DKK1was negatively correlated with SFRP4and Wnt1in SCC group (P<0.05). The expression of SFRP4was positively correlated with Wnt1in SCC group (P<0.05).    Conclusion     The roles of SFRP4and Wnt1are synergistic interactions in the development of SCC. DKK1is an inhibiting factor of SCC

Key words: uterine cervical neoplasms, carcinoma, squamous cell, Wnt1 protein, immunohistochemistry, dickkopf 1, SFRP4