Abstract: Objective To observe clinical effect of the compound lidocaine cream to inhibit the cardiovascular responses of tracheal extubation after the cerebral aneurysm clipping surgery. Methods 32 patients (ASA I - II level) of cerebral aneurysm clipping surgery were randomly divided into lidocaine cream group (L) and the control group (C group), 16 cases in each group. L group was coated with 5% lidocaine cream in the front of the tracheal tube before intubation, group C coating the same amount of vaseline. Recorded two groups such as age, height, weight in general. Recorded operation time, anesthesia time, dosage of remifentanil, dosage of fluid replacement. The SBP, DBP, and HR of before anesthesia (T1), 2min before extubation (T2), extubation (T3), 2min after extubation (T4) in patients were recorded. Calculation of the two groups at T3and T2 to SBP and DBP, HR difference (ΔSBP, ΔDBP, ΔHR), and calculate the ratio of the difference between T2 to corresponding data. Results The SBP and DBP, HR in T3, T4point of group L significantly lower than group C (P <0 05). The ratio of ΔSBP, ΔDBP, ΔHR and the corresponding data of T2 of group L was significantly lower than group C (P <0 05). Conclusion Tracheal tube coated compound lidocaine cream before intubation can effectively inhibit the cardiovascular responses of extubation after cerebral aneurysm clipping surgery.

Key words: 心血管反应