Abstract:

[Abstract]   Objective   To compare the effects of telmisartan and (or) amlodipine on the reversal left ventricular re?
modeling in two-kidney one clip hypertensive rats.  Methods   A total of50healthy male SD rats were randomly divided into5groups (n=10): two-kidney one clip renal hypertensive (2KIC) model group, sham group, telmisartan (10mg/kg) group, am?lodipine (2.5mg/kg) group and telmisartan (10mg/kg) +amlodipine(2.5mg/kg) group. Themodel of two-kidney one clip re?nal hypertensive rats was established. The tail arterial blood pressure was detected once a week. After20weeks, rats were sacrificed and specimens were collected. The left ventricular mass index (LVMI) was assessed. The myocardial ultrastructural changes were observed by electron microscope. Values of plasma renin activity (PRA), angiotensionⅡ (AngⅡ) and atrial natriuretic peptide (ANP) were measured by enzyme linked immunosorbent assay (ELISA).  Results   Compared with sham group, the levels of systolic blood pressure (SBP), LVMI, PRA, AngⅡ and ANP were significantly higher in2KIC group (P<0.01). Compared with2KIC group, values of SBP, LVMI, PRA and ANP were significantly lower in telmisartan group and amlodipine group (P<0.01), but the value of AngⅡwas significantly higher (P<0.01). The levels of SBP, LVMI, AngⅡand ANP were significantly lower in combined medication group than those of single drug medication group (P<0.01). There was no significant difference in the plasma PRA level between those groups (P>0.05). Results of myocardial electron microscopy showed that the left ventricular remodeling was significantly improved in combined treatment group.   Conclusion   Telmisartan and amlodipine can effectively improve the left ventricular remodeling induced by hypertension. There was more effective therapy using both medications together.

Key words: benzoates, benzimidazoles, amlodipine, hypertension, renal, ventricu1ar remodehng, telmisartan