Abstract:

[Abstract]   Objective   To analyze the relationship between plasma aldosterone level and gestational diabetes melli?
tus.   Methods   All subjects were divided into three groups (n=20 in each group): gestational diabetes mellitus (GDM) group，pregnancy with normal glucose group， non-pregnant healthy women group. Pre-pregnant body mass index (BMI) was calculated, and fasting blood glucose (FBG), blood lipid level, Fins, HOMA-IR index, RASS, PRA, ATIi and ALD were examined besides glucose intolerance test.   Results   The plasma ALD level was significantly higher in GDM group than that of NGT group and control group（pmol/L： 1 130.15±135.45 vs 1 053.98±108.86 vs 544.31±127.97）. The plasma ALD level was positively correlated with FBG,1 h PBG ,2 hPBG， Fins , HOMA-IR and blood triglyceride (r=0.657, 0.757, 0.713, 0.429， P＜0.05)， but negatively correlated with HDL-C（r=-0.267， P=0.039）. Stepwise regression analysis revealed that plasma aldosterone was the independent risk factor of GDM.   Conclusion   RASS is excessively activated in pregnancy, which contributes to gestational diabetes mellitus.

Key words: diabetes, gestational, aldosterone, regression analysis, Insulin Resistence