Abstract: Objective To detect the anesthetic efficiency of etomidate emulsion，which was used in total intravenous anesthesia (TIVA) combined with remifentanil. Methods 50 patients in ASA Ⅰ～Ⅱ underwent elective general anesthesia for middle and lower abdominal surgery were selected, the operations time were all within 3 hours, these patients were randomly divided into two groups: group E(etomidate) and group P(propofol), they were induced with the same method, we transfused etomidate and remifentanil in group E and propofol and remifentanil in group P continuously to maintain anesthesia, maintain the bispectral index（BIS）between 40 and 60,which guided the transfused speed of etomidate and propofol.; The hemodynamic changes of the patients in the two groups were recorded; The transfused speed and the dosage inside unit time of etomidate and propofol were recorded and calculated; The consciousness recover time of patients were recorded. The happenings of postoperative nausea and vomiting, dysphoria were recorded. Results The hemodynamic changes were stable in the two groups; Maintained the BIS between 40 and 60,the intravenous speed of etomidate was( 7.74±1.11) ug.kg-1.min-1,the dosage was（1.61±0.39）bottle per hour; The intravenous speed of propofol was(5.62±0.83) ug.kg-1.min-1,the dosage was（1.92±0.47）bottle per hour; The consciousness recover time of patients in the two groups were close, there was no happening of postoperative nausea and vomiting、dysphoria during anesthesia resuscitation; Conclusion Combined with remifentanil in total intravenous anesthesia to maintain anesthesia within 3 hours, etomidate emulsion had higher anesthetic efficiency and cost performance compared with propofol.

Key words: Etomidate emulsion, propofol, total intravenous anesthesia, Remifentanil