Abstract: Objective To investigate the anesthetic effect of dexmedetomidine combined with propofol in mammotome operation for breast. Methods Sixty patients underwent mammotome operation for multiple solid masses in breast were randomly divided into observation group and control group (n=30 for each group). The control group was anesthetized with propofol. The observation group was anesthetized with dexmedetomidine and propofol. Data of blood pressure, heart rate, oxygen saturation, the time of jaw support, the time of postoperative recovery, the amount of propofol at the beginning of anesthesia, the start of surgery, 5 minutes after the start of surgery, the end time of surgery and the VAS score, Ramsay sedation score at 1 hour after surgery were compared between the two groups. Results There were no significant differences in blood pressure and oxygen saturation between the two groups at each time point (P＞0.05). The heart rates at the beginning of surgery, 5 minutes after the start of surgery and at the end of surgery were lower in the observation group than those of the control group (P＜0.05). The heart rates at the beginning of surgery and 5 minutes after the start of surgery were lower than at the start of anesthesia and the end of surgery in the observation group (P＜0.05). The time of jaw support, recovery time and propofol dosage were shorter in the observation group than those in the control group (P＜0.05). The VAS score was lower at 1h after operation in the observation group than that of the control group. There was no significant difference in the Ramsay score between the two groups (P＞0.05). Conclusion The use of dexmedetomidine combined with propofol on mammotome operation for breast can reduce the amount of propofol. The effect of anesthesia and postoperative sedation is good, but heart rate decreases, which is not suitable for patients with sinus bradycardia and atrioventricular block.

Key words: propofol, anesthesia, breast, dexmedetomidine, mammotome operation