Abstract: Abstract Objective：To evaluate the analgesic efficiency and safety of patient-controlled analgesia (PCIA) effects with dezocine and fentanyl following uvulopalatopharyngiplasty (UPPP) surgery. Methods: Forty ASA I～Ⅱpatients undergoing UPPP surgery were randomly divided into two groups equally with 20 cases each: group F (fentanyl 16μg／kg) and group D (dezocine 0.8mg/kg). The drugs including 5mg of droperidol were diluted with normal saline to 100 ml and were given via PCIA after surgery. The PCIA rate was 2 ml／h, bolus 1.0 mL, lockout time 15 min. Postoperative analgesia efficiency was assessed by Visual Analogue Scale (VAS) and Ramsay score at 1, 3, 6, 12, 24h. The circulatory, ventilatory function , PCIA pressing times and side effects were also recorded. Results：The patients in both groups showed good pain relief. In group F, VAS scores were lower while Ramsay scores were higher than those of group D at 1h (P < 0.05). There were no significant differences in VAS and Ramsay scores in the two groups at the other time (P > 0.05). In the two groups, there were no significant differences in PCIA pressing times (P > 0.05). In group F, MAP and HR were lower than those of group D at 1-3 h (P < 0.01或0.05). In group F, SPO2 were lower than that of group D at 1h (P < 0.01). In group F, the nausea and vomiting and the respiratory depression were higher than those of group D (P < 0.05). There were no significant differences in other side effects in the two groups (P > 0.05). Conclusion: Comparing with fenatanyl, postoperative patient-controlled intravenous analgesia with dezocine may be the preferred analgesic following UPPP surgery.

Key words: dezocine, fenatanyl, patient-controlled intravenous analgesia, obstructive sleep apnea syndrome, uvulopalatopharyngiplasty