Abstract: Objective：To investigate the pathogen epidemiology and risk factors of central venous catheter related bloodstream fungal infection (CVC-RBFI) in intensive care unit（ICU）, in order to provide useful information for the prevention and treatment of CVC-RBFI. Methods：The clinical data of 20 cases patients with CVC-RBFI in ICU between July 2006 and December 2010 were retrospectively analyzed, and compared with the control which the clinical data of 35 cases patients with central venous catheter related bloodstream bacteria infection (CVC-RBBI) at the same time. Meanwhile the pathogen epidemiology and drug resistance also were analyzed. Results：CVC-RFBI accounted for 36.36%（20/55）of central venous catheter related bloodstream infection(CVC-RBI). Non-albicans candida accounted for 60%（12/20）of fungal pathogen. The susceptibility rates of non-albicans candida to zole were 50.00%. The independent risk factors of CVC-RBFI were the existing more drainage tubes of body（OR= 8.938，P<0.05）and post major operations（OR= 11.250，P<0.05）. Conclusion： CVC-RFBI is the main party of CVC-RBI in ICU. It would be strengthened to prevent and treat to the risk factors of CVC-RBFI synthetically.

Key words: central venous catheter, fungal, bloodstream infection, risk factors