Abstract: Objective To study the expressions of p15 and nm23 in human uterine endometrial carcinoma and to explore the role and clinical significance of the genes in the development of the disease. Methods The expression of p15 and nm23 in 60 specimens of uterine endometrial carcinoma was examined by immunohistochemistry S-P methods. Results the expression of p15 was associated with pathological grades (p<0.05). The expression of nm23 was associated with operation-pathological stages and lymph node metastasis (p<0.05).There was positive correlation between p15 expression and nm23 expression in the disease (P<0.01). Conclusions Low expression of p15 and nm23 may contribute to the development of uterine endometrial carcinoma, and the expressions of the genes in the malignant tumor is consistency.

Key words: Endometrial neoplasms, genes , tumor suppressor, p15, nm23