Abstract: [ABSTRACT] AIM To observe the effects of H102 on related protein of synaptophysin of APP trangenic mouse. METHODS The APP transgenic mice were radomly divided into three groups which are modle group ,H102 treatment group, and the control group which of C57BL/6J mice with the same age and background . Modle geoup and normal control group were treated with saline solution while the H102 treatment group was treated with compounds (80μmol/L H102 in saline solution ),med icine or saline was infused in lateral cerebral ventricle every day.after flished that do water maze testing Immunohistichemical stain and westen blot were done with synapse,PSD-95, shank1.RESULTS [1]Morris water maze test showed that the mean escape latent period(MELP) ,the time of the mice across the flat, and the time of traversing through flat roof,and the time which the mice stay in the third space,were was obviously shorten after H102 treatment compare with the modle group（P<0.01),and similer to the nomal group(P>0.05).[2]The content of synapse,PSD-95 and shank1 were highter in H102 treatment group than in modle group (P<0.01)and simile to the nomal group.CONCLUSION H102 can improve the APP trangenic mouse’ ability of remember obviously,and the content of synapse,PSD-95 and shank1 in APP trangenic mouse’ briarn become higher.H102 is a greate and effective durg which will be treated with AD.

Key words: Alzheimer’s disease1, APP transgenic mice2, synapse3, PSD-954, shank15.