Abstract: Objective: To investigate the preventive effects of intensive doses of atorvastatin on contrast induced nephropathy（CIN） in patients undergoing percutaneous coronary intervention（PCI）.Methods: Two hundred and forty-two patients who are about to undergo PCI in Tianjin Chest Hospital are randomly divided into eithe conventional treatment group（n=120） or intensive treatment group（n=122）.Patients in the two groups are given atorvastatin 20mg and 40mg respectively dialy two days before PCI. The levels of blood urea nitrogen（BUN）, serum creatinine（Scr）, creatinine clearance rate （Ccr）, estimated glomerular filtration rate （eGFR）, interleukin-6（IL-6）, β2-microglobulin（β2-MG）, C-reactive protein（CRP）, tumor necrosis factor-α（TNF-α）, alanine aminotransferase（ALT）were measured at admission and 72h after the procedure. Result:（1）In the intensive treatment group, only 3 patients present with CIN，the incidence of CIN was 2.5%;In the conventional treatment group, CIN occur in seven patients, the incidence of CIN was 5.8%（χ2=1.74，p>0.05）.（2）There was no statistically difference in the levels of BUN、Scr、IL-6 、β2-MG、CRP、TNF-α at admission（P>0.05）. 72h after the procedure, the levels of IL-6, β2-MG, CRP, TNF-α were lower in intensive treatment group than the conventional treatment group, and the levels of Ccr and eGFR were higher in intensive treatment group. Conclusion: Although there was no statistically difference in the incidence of CIN between the 2 groups , the statistically differences in biochemical parameters indicate the tendency of renal protection of intensive treatment before PCI. The protection mechanism may be due to the anti-inflammatory effects. Therefore, the adminstintion of intensive atrovtatin before PCI can be beneficial in the prevention of CIN.

Key words: atorvastatin, contrast induced nephropathy, prevent, coronary heart disease, percutaneous coronary intervention