Abstract: [Abstract ] Objective To contrast the changes of serum calcium, phosphorus and iPTH levels through using of the low flux dialyzer with high flux dialyzer alternately or continually.To approach an effective and feasibility method preventing from hyperphosphataemia and high iPTH level. Methods To choose 40 MHD cases in our hospital who were used the Sureflux-130G low flux dialyzer more than three months. The patients were called the low flux hemodialysis group ( LFHD ), as their own control group. The patients 40 of casses were divided into high flux dialysis A and B two groups ( HFHD-A, HFHD-B ),20 cases in each group. HFHD-A group: to use of 130G and 150U dialyzer alternately; HFHD-B group: to use of 150U dialyzer continually. First, to detection serum BUN, Scr, Hb, Alb, Ca, P, iPTH levels before and after treating with 130G, 150U dialyzer single and contrast their solute reduce rate .Then to measure above mentioned observations after the therapy for 3 months and observe the relieve dugree of Skin pruritus Results After single use of 130G, 150U dialyzer, serum BUN, Scr, UA, Hb, Alb, Ca decrease rate, no significant difference ( P> 0.05 ); serum P, iPTH levels decrease rate showed significant difference ( P < 0.05 ), HFHD group was superior to LFHD group. After the therapy for 3 months, HFHD-A and HFHD-B groups serum P, iPTH levels decreased significantly comparing with LFHD group, showed significant difference ( P < 0.05 ), the serum P removal effect became more remarkable in HFHD-B group（P<0.01）. With HFHD for 1 months, skin itching symptoms that have improved significantly, HFHD-A, HFHD-B two group skin itching relieving degree respectively: 45.5%, 66.7%; effective:72.7%,91.7%; invalid: 27.2%, 0.83%. 3 months after the show: effect: 63.6%, 83.3%; efficiency reached 100%. Skin itching relieving degree of group HFHD-B was significantly higher than that of HFHD-A group. Conclusion It can reduce the serum phosphorus, iPTH levels effectively after use high flux dialyzer alternately or continually. It was important clinical significance to remission secondary hyperparathyroidism, reduce cardio-cerebro-vascular complications decrease mortality in MHD patients.

Key words: Hemodialysis, high flux Hemodialyzer, hyperphosphataemia