Abstract: To discuss the influence of different variety of mouse on the Model of Acute Pancreatitis association Lung Injury.Methods：The AP model was induced by injecting caerulein into the cavity of mice.Caerulein(50 ug／kg body weight)in 0．9％ NaC1 at hourly intervals for 12h、20h；The control animals received the same volume of 0．9％ NaCl without caerulein（0.2ml）.The animals were killed after the last intraperitoneal injection.The severity was evaluated in terms of amylase level，histological changes.To observate the differences between KM, ICR and BALB / C at 12h, 20h.Results：BALB/C 12h experimental group with acute pancreatitis complicated with acute lung injury model succeed：pathology of pancreatic acinar appeared wide variability，and vacuolization acinar necrosis, a large number of infiltrating inflammatory cells.Interstitial and part of the alveolar space have more neutrophils, atelectasis, the gap widened alveolar. KM, ICR was not successful. 20h experimental group found that BALB / C, Kunming mouse model successful, ICR mice with acute pancreatitis only minor damage. Conclusion Balb / C mice of drug response, and less drug use, saving time and costs for acute necrotizing pancreatitis model.

Key words: Caerulein mouse pancreatitis lunginjury Balb/c