Tianjin Medical Journal

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The Evaluation of the Michigan Neuropathy Screening Instrument in the Diagnosis of Diabetic Peripheral Neuropathy

ZHANG Chun feng1,XIE Yun 2   

  1. 1. Department of Neurology, Metabolic Disease Hospital of Tianjin Medical University, The Key Laboratory of Hormone and Development of the Ministry of Health , Tianjin 300070, China
    2. Department of Neurology, Metabolic Disease Hospital of Tianjin Medical University, The Key Laboratory of Hormone andDevelopment of the Ministry of Health , Tianjin 300070, China
  • Received:2012-05-09 Revised:2012-09-17 Published:2013-03-15 Online:2013-03-15
  • Contact: ZHANG Chun feng

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Abstract:

[Abstract] Objective  To investigate the value of the Michigan Neuropathy Screening Instrument (MNSI) in the diagnosis of diabetic peripheral neuropathy (DPN). Methods  A total of 267 patients with diabetes mellitus underwent the measurements of MNSI and neural electrophysiological test. All of the participants were divided into three groups based on MNSI score: 112 patients in group A (score 0-2.4), 88 in group B (score 2.5-4.4) and 67 in group C (score≥4.5). The differences of gender, age, history of diabetes and neural electrophysiological test results were compared between three groups. The stepwise logistic regression was used to analyze the effect of MNSI questionnaire for the DPN. The relationship between the MNSI questionnaire, exam score and the index mentioned above was analyzed. Results  (1) The patients in group A were much younger and had a shorter history of diabetes than those in group B and group C. Compared with the other two groups, patients in group C got significantly higher perception of non-waveform in the neuroelectricity test (P ＜0.05). (2) There were significantly higher values, including the amplitude of the motor nerve of the posterior tibial nerve, the nerve conduction velocity of the sensory nerve and motor nerve, in group A than those of group B and group C. The diagnosis rate of DPN was significantly lower in group A than that of group B and group C (P ＜0.05). (3) The questions of 1, 2, 11 and 14 in MNSI were the risk factors for DPN. (4) The MNSI questionnaire was positively correlated with age and history of diabetes, and negatively correlated with the amplitude of motor nerve of posterior tibial nerve and sensory nerve conduction velocity of both legs.The MNSI score was positively correlated with age, history of diabetes and body mass index, and negatively correlated with the amplitude of motor nerve of posterior tibial nerve and sensory nerve, motor nerve conduction velocity of both lower limbs (P ＜0.05). Conclusion  Regard the MNSI questionnaire 4 and exam score 2 as a cut-off point, higher score will get a high risk of DPN, and the nerve conduction will be worse.

Key words: Diabetes, Michigan Neuropathy Screening Instrument(MNSI), Neural Electrophysiological Test（NET）, Body Mass Index(BMI), Diabetic Peripheral Neuropathy（DPN）