Abstract: Objective:To observe the express level change of RhoA and ROCK signal pathway in insulin resistence Rat and To identify the role of telmisartan on the expression of RhoA and ROCK signal pathway in insulin resistence Rat small cornary artery tissue. Methods:There were 30 male Sprague-Dawley (SD) Rats was randomly divided into 3 groups,10 in each group.The control group was feed with normal diet ,10 in Insulin resistance group (creat model by high fructose diet plus Streptozotocin（25mg/Kg） injection ),10 in telmisatan group (insulin resistance plus telmisartan5mg/kg/d). 8 weeks later,Coronary arteries were isolated for the RT-PCR and Westen Blot assay to identify RhoA,ROCK1,ROCK2 mRNA and proten expression level.Results : Compared with control group, RhoA proten express level down regulated but ROCK1mRNA express level was up regulated in IR group. After interfere by telmisartan , RhoA proten expression was remarkably higher than IR group (P=0.043) .there were no statistical significance of RhoA,ROCK1mRNA and ROCK1,ROCK2 proten expression between Tel and IR group .Conclusions:Telmisartan can reverse the RhoA protein down regulation in IR rat’s coronary artery ,but only have a limited affect on RhoA mRNA ,ROCK1 and ROCK2mRNA and protein expression level in insulin resistance rat’s coronary artery.

Key words: Insulin Resistance, Coronary Arterys, Telmisartan, RhoA, ROCK