Abstract: Objective To investigate the relationship of the blood glum variability and microalbuminuria(MAU)in type 2 diabetic patients with well-controlled glycosylated hemoglobin(HbAlc)。 Methods One hundred and thirsty-one type 2 diabetic patients with HbAlc under 7.0％ were divided high UAER group and normal UAER group。 Using the continuous glucose monitoring system (CGMS)，blood glucose fluctuate coefficient（BGFC），mean blood glucose（MBG）, percentage of time(PT) below 3.9mmol/L and above 7.8 and 11.1mmol/L were received。Then the data were analysis by the statistical analysis。Results (1)The course of disease ，uric acid （UA），fasting C-peptide, BGFC and PT(>7.8mmol/L) were significantly higher than those of the normal UAER group (p<0.05或p<0.01). (2)The course of disease ，urine albumin exclusion rate （UAER），serum glycosylated albumin（GA），MBG ，PT(>7.8mmol/L) and PT(>11.1mmol/L) in BGFC >1.5 group were higher than those of the BGFC<1.5 group (p= 0.016、0.022、0.001、<0.001、<0.001、<0.001）.（3）、Spearman regression analyses indicated that course of disease and UA and fasting C-peptide and BGFC were the independent influential factors of UAER（r=0.249，p=0.004；r=0.212，p=0.015 ；r=-0.199，p=0.023 ；r=0.191，p=0.029）. Logistic regression analyses indicated that UA and fasting C-peptide and BGFC were the risk factors of UAER (OR=1.349，p= 0.036；OR=1.005 p= 0.032；OR=1.582 p= 0.027) 。Conclusion In well-controlled patients with type 2 diabetes，course of disease and PT(>7.8mmol/L、>11.1mmol/L) and GA were the main factors influencing glucose variability。 The blood glucose variability is one of the risk factors for UAER。

Key words: Diabetes mellitus, type 2, Urine albumin exclusion rate, Blood glucose variability